Stem Cell Homing Factor, CCL7, Expression in Mouse Models of Stress Urinary Incontinence

• DOI: 10.1097/spv.0b013e3182a331a9
• Publication Date: 2013-10-28T09:58:43Z
• Authors: Adonis K. Hijaz; Kerry O. Grimberg; Mingfang Tao; Brian Schmotzer; Zhina Sadeghi; Yi-Hao Lin; Michael Kavran; Ahmet Ozer; Nan Xiao; Firouz Daneshgari
• Keywords: CCL7

Animal models of vaginal distention (VD) have demonstrated increased expression chemokine (C-C motif) ligand 7 (CCL7) In this study, we investigated the CCL7 in mice simulated birth trauma-induced urinary incontinence using VD and pudendal nerve transection (PNT).Forty-nine were divided into 6 groups: VD, sham PNT, anesthesia, age-matched controls. The urethra, vagina, rectum harvested for immediately or 24 hours after assigned procedure. Venous sampling quantification serum was also performed. An analysis variance model used to compare relative each group.Urethral group significantly higher than control (P < 0.01). There no difference urethral anesthesia groups compared with No statistically significant noted rectal between any except PNT. Statistically differences PNT 0.01 all) group.This study demonstrates overexpression but not This suggests that injury does contribute overexpression. a translational potential where measurement could be as surrogate delivery.