De Novo Cancers Arising in Organ Transplant Recipients are Associated With Adverse Outcomes Compared With the General Population

• DOI: 10.1097/tp.0b013e3181a238f6
• Publication Date: 2009-05-21T21:12:27Z
• Authors: Yun Miao; Jason J. Everly; Thomas G. Gross; Amit D. Tevar; M Roy First; Rita R. Alloway; E Steve Woodle
• Keywords: Adult; Male; Lung Neoplasms; Patient Selection; Breast Neoplasms; Organ Transplantation; Middle Aged; Survival Analysis; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Testicular Neoplasms; Neoplasms; Colonic Neoplasms; Humans; Female; Registries; Survivors; Neoplasm Staging

Transplant recipients are at increased risk of malignancy; however, the influence transplantation on cancer outcomes has not been rigorously defined. The purpose this study was to examine individual cancers.De novo nonsmall cell lung cancer, colon breast prostate bladder renal (RCC), and malignant melanoma data in 635 adult (>18 years age) transplant (from Israel Penn International Tumor Registry) were compared with from 1,282,984 adults general population Surveillance, Epidemiology, End Results database).Compared population, patients more likely have early stage (AJCC 0-II) RCC, but advanced >II) melanoma. Compared disease-specific survival worse for (all stages), (stage II), III), II, III, IV), RCC IV). Multivariate analyses demonstrated be a negative factor each studied, diagnosis most profound predictors.These indicate that, several common cancers, experience than population. also suggest that cancers aggressive biologically time diagnosis.