Factors Associated With Primary Graft Failure After Heart Transplantation

• DOI: 10.1097/tp.0b013e3181e6f1eb
• Publication Date: 2010-07-09T10:50:31Z
• Authors: Mark J. Russo; Alexander Iribarne; Kimberly N. Hong; Basel Ramlawi; Jonathan M. Chen; Hiroo Takayama; Donna M. Mancini; Yoshifumi Naka
• Keywords: Primary (astronomy)

Background. Primary graft failure (PGF) is the most common cause of short-term mortality after cardiac transplantation. The low prevalence PGF has limited efforts at identifying risk factors for its development. purpose this study was to evaluate associated with heart Methods. Deidentified data were obtained from United Network Organ Sharing. Analysis included transplant recipients more than or equal 18 years transplanted between January 1, 1999, and December 31, 2007 (n=16,716). studied perspective “hard outcomes” including death retransplantation within 90 days due failure, not related rejection infection. Multivariate regression analysis performed (backward, remove P>0.15) assess simultaneous effect multiple variables on PGF. odds ratio 95% confidence interval reported each factor. Results. Among 414 transplants complicated by PGF, 354 (85.5%) died 60 (14.5%) retransplanted. accounted 23.4% (n=364) all deaths (n=1555) in first posttransplant. Categories pretransplant included: ischemic time, donor gender, age, multiorgan donation, center volume, extracorporeal membrane oxygenation, mechanical circulatory support, etiology reoperative transplant. area under receiver operative characteristic curve multivariate model 0.764 (0.733–0.796). Conclusions. Pretransplant recipient characteristics are Identification may aid understanding mechanisms underlying matching donors diminish high complication.