Impact of Norovirus/Sapovirus-Related Diarrhea in Renal Transplant Recipients Hospitalized for Diarrhea

• DOI: 10.1097/tp.0b013e31821c9392
• Publication Date: 2011-05-07T07:29:46Z
• Authors: Damien Roos-Weil; Katia Ambert-Balay; Fanny Lanternier; Marie-France Mamz...; Dominique Nochy; Pierre Pothier; Véronique Avettan...; Dany Anglicheau; Renaud Snanoudj; Lynda Bererhi; Eric Thervet; Marc Lecuit; Christophe Legendre; Olivier Lortholary; Julien Zuber
• Keywords: Sapovirus

Background. Diarrhea of unspecified cause frequently occurs after renal transplantation and is usually ascribed to mycophenolic acid toxicity. Norovirus (NoV) sapovirus (SaV) have been sporadically reported chronic diarrhea in immunocompromised patients. Methods. We undertook a retrospective study (2008–2009) examine the clinical epidemiologic significance NoV SaV infections adult transplant recipients hospitalized for acute or diarrhea. Results. Ninety-six were at our institution during 16-month period, 87 whom included study, including 46 patients with Among 41 unexplained diarrhea, 20 screened NoV/SaV, 16 positive. Fifteen them (94%) had When compared bacterial parasitic infections, NoV/SaV associated greater weight loss time admission, 8.7-fold longer duration symptoms more frequent need dosage reduction. Eighty-one percent NoV/SaV-associated experienced failure. Five one subsequently biopsy-diagnosed active graft rejection oxalate nephropathy, respectively. Ten 14 who underwent longitudinal stool's clearance exhibited prolonged viral shedding period median 289 days (107–581 days). Conclusions. Our indicates that infection causes posttransplant potentially complicated by severe kidney impairment.