Association of Cytomegalovirus Infection and Disease With Recurrent Hepatitis C After Liver Transplantation

• DOI: 10.1097/tp.0b013e3182472876
• Publication Date: 2012-03-09T01:34:16Z
• Authors: Wendelyn Bosch; Michael G. Heckman; Surakit Pungpapong; Nancy N. Diehl; Jefree A. Shalev; Walter C. Hellinger
• Keywords: Cytomegalovirus; Hepatitis C; Betaherpesvirinae; Liver disease

Cytomegalovirus (CMV) has been inconsistently associated with recurrent hepatitis C virus (HCV) after liver transplant (LT).A retrospective study of 347, donor or recipient CMV seropositive, first LT recipients transplanted for HCV was performed to evaluate the associations infection and disease occurring within 1-year primary endpoints allograft inflammation grade ≥2 fibrosis stage ≥2. Associations were evaluated using multivariable Cox regression models.CMV occurred in 111 (32%) 24 (7%) patients, respectively. Hepatic 221 (64%) 140 (40%) increased risk (relative [RR], 1.52; P=0.033). (RR, 3.40; P<0.001), although not significant, 2.03; P=0.052). These did differ significantly according seropositivity.Our results support an association between recurrence LT. Investigation prevention as a strategy mitigate is warranted.