Randomized Clinical Trial of Transversus Abdominis Plane Block Versus Placebo Control in Live-Donor Nephrectomy

• DOI: 10.1097/tp.0b013e31825c1697
• Publication Date: 2012-08-17T06:50:31Z
• Authors: Sarah A. Hosgood; Umasanker M. Thiy...; Harriet F.L. Nich...; Inthira Jeyapalan; Michael L. Nicholson
• Keywords: Blinding

Background Laparoscopic surgery reduces pain after donor nephrectomy; however, most patients still require a significant amount of postoperative parenteral opiate analgesia. Therefore, there is need to investigate techniques that might further reduce pain. This study assessed the safety and efficacy using transversus abdominis plane (TAP) block in randomized, double-blind, placebo-controlled trial. Methods Forty-six were analyzed trial randomized undergo TAP procedure with either bupivacaine (n=24) or saline placebo (Control n=22) injected into muscle plane. Prefilled syringes dispensed group allocation concealed maintain blinding. After surgery, morphine, level pain, measures recovery recorded. Results The morphine used 6 hr was significantly lower receiving compared control (presented as mean [SD], 12.4 [8.4] vs. 21.2 [14.0] mg; P=0.015). However, total similar both groups 45.6 [31.4] 52.7 [28.8] P=0.771. Patients experienced less on days 1 (score, 19 [15] 37 [20]; P=0.003) 2 11 [10] [13]; P=0.031). Recovery hospital stay groups. There no complications associated procedure. Conclusion beneficial reducing early requirements laparoscopic live-donor nephrectomy.