Proteinuria and Outcome After Renal Transplantation

• DOI: 10.1097/tp.0b013e318295852c
• Publication Date: 2013-05-25T12:05:13Z
• Authors: Kathryn K. Stevens; Rajan K. Patel; Shona Methven; Marc J. Clancy; Jonathan G. Fox; Alan G. Jardine; Colin C. Geddes
• Keywords: Adult; Male; Kaplan-Meier Estimate; Middle Aged; Kidney; Kidney Transplantation; 6. Clean water; 3. Good health; Proteinuria; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; ROC Curve; Predictive Value of Tests; Risk Factors; Creatinine; renal transplant; Multivariate Analysis; Humans; Female; proteinuria; Follow-Up Studies; Proportional Hazards Models

Proteinuria is associated with poorer outcomes in renal transplant recipients. Fractional excretion of total protein (FEPR) may better reflect kidney damage than urine protein-to-creatinine ratio (PCR).We assessed FEPR (FEPR = [serum creatinine × protein] / creatinine], %) and PCR ([urinary protein/urinary creatinine] 1000, mg/mM) 1 year after first transplantation as predictors failure. The primary endpoints were failure death. use the tests was analyzed by constructing receiver operator characteristic curves comparing area under curve. Using analysis, patients stratified into high- low-risk groups.Two hundred nineteen recipients followed up for a median 4.9 years. At 2.7 years, 11.4% (n=25) transplants failed. Eight percent (n=17) died. curve higher (0.92 vs. 0.84). Patients an 0.019% or had 3.4-fold (P=0.003) increased risk 2.3-fold (P=0.02) death compared those less 0.019%. 97 mg/mM greater 2.1-fold (P=0.04) 1.6-fold (P=0.04). In multivariate analysis time to dependent variable, independent (hazards ratio, 1.07 [P=0.013] 1.03 [P=0.03], respectively).FEPR at are failure, but be superior.