Diagnostic Value of CSF Biomarker Profile in Frontotemporal Lobar Degeneration

• DOI: 10.1097/wad.0b013e3181610fea
• Publication Date: 2009-03-05T15:08:57Z
• Authors: Elisabeth Kapaki; George P. Paraskevas; Sokratis G. Papag...; Anastasios Bonakis; Nikolaos Kalfakis; Ioannis Zalonis; Demetris Vassilop...
• Keywords: Frontotemporal lobar degeneration; Primary progressive aphasia; Tau protein

Background Cerebrospinal fluid (CSF) biomarkers have been increasingly studied in dementia clinical and differential diagnosis. Methods We assessed levels of total tau protein (τT), phosphorylated at threonine 181 (τP-181), β-amyloid1-42 (Aβ42) 34 patients with frontotemporal lobar degeneration (FTLD), 76 Alzheimer disease (AD) cases, 93 controls (CTRL). Double sandwich enzyme-linked immunosorbent assays (Innogenetics) were used for measurements. Results Total τ was significantly increased Aβ42 decreased FTLD AD as compared CTRL. CSF τP-181 only AD. The τT/Aβ42 ratio successfully discriminated from CTRL a 86.7% specificity 80.6% sensitivity, whereas the τT alone more specific (95.7%) but less sensitive (64.75%). For discrimination AD, better (90.3% sensitivity 64.5% specificity) other or combination, (68.4% 85.7%, respectively). Subtype analysis revealed that most AD-like profile observed motor neuron signs, non-AD primary progressive aphasia. Conclusions Combined may be useful best possible antemortem