Neuronal Bursting Properties in Focal and Parafocal Regions in Pediatric Neocortical Epilepsy Stratified by Histology

• DOI: 10.1097/wnp.0b013e3181fe06d8
• Publication Date: 2010-11-01T07:24:00Z
• Authors: Charles J. Marcuc...; Andrew K. Tryba; Wim van Drongelen; Henner Koch; Jean Charles Viemari; Fernando Peña-Ortega; Erin L. Doren; Peter Pytel; Marc Chevalier; Ana Mrejeru; Michael H. Kohrman; Robert E. Lasky; Sean M. Lew; David M. Frim; Jan-Marino Ramirez
• Keywords: Bursting; Histology

To test the hypothesis that focal and parafocal neocortical tissue from pediatric patients with intractable epilepsy exhibits cellular synaptic differences, authors characterized propensity of these neurons to generate (a) voltage-dependent bursting (b) synaptically driven paroxysmal depolarization shifts. Neocortical slices were prepared resected epilepsy. Multiunit network activity simultaneous whole-cell patch recordings made three patient groups: (1) those normal histology; (2) mild severe cortical dysplasia; (3) abnormal pathology but without dysplasia. Seizure-like was by population concomitant in intracellularly recorded (n = 59). The found significantly more N-methyl-d-aspartic acid-driven versus dysplasia (P < 0.01). Occurrence shifts burst amplitude duration related type: or 0.05). show functional differences between exist. There are groups different histology, properties can be associated distinction tissue.