Effects of stress during reactivation on rewarding memory

• DOI: 10.1097/wnr.0b013e3281ac212e
• Publication Date: 2007-06-22T08:04:42Z
• Authors: Mei Zhao; Zhang-Yin Zhang; Hai-feng Zhai; Yi Qiu; Lin Lu
• Keywords: Conditioned place preference; Taste aversion

When a stabilized memory is recalled or reactivated, it becomes labile and sensitive to disruptors such as protein-synthesis inhibitors. Previous evidence demonstrates that stress modulates different aspects of memory. The role during reactivation on rewarding aversive not known, however. This study examines the effects using conditioned place preference aversion paradigm. Rats were trained acquire sucrose cocaine-conditioned naloxone-conditioned aversion. Subsequently, rats reexposed previous sucrose-paired, cocaine-paired naloxone-paired chamber for 10 min before experiencing stressful Morris water maze. All tested after water-maze task. After 5-day repeated exposure previously reward-paired stress, disappeared sucrose-conditioned was reversed; however, significantly changed. Our results provide first may have been reduced by exposing reexposure context, which suggests manipulations drug can potential treatment addiction.