Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients

• DOI: 10.1097/yic.0b013e32832e5b0d
• Publication Date: 2009-08-10T09:07:00Z
• Authors: Alessandro Serretti; Raffaella Calati; Isabelle Massat; Sylvie Linotte; Siegfried Kasper; Yves Lecrubier; Roser Sens-Espel; Joseph Bollen; Joseph Zohar; Jacques Berlo; Patricia Lienard; Diana De Ronchi; Julien Mendlewicz; Daniel Souery
• Keywords: Depression

Cytochrome P450 genes are involved in the metabolism of antidepressants and could influence treatment response. The aim this study was to investigate role allelic variations cytochrome CYP1A2, CYP2C9, CYP2C19 CYP2D6 antidepressant response remission rates. Two hundred seventy-eight patients affected by major depression, responders (N = 81) nonresponders (N=197) at least one adequate treatment, were recruited with a multicentre design for resistant depression genotyped all relevant variations. None considered metabolic profiles (e.g. poor, intermediate, extensive ultrarapid metabolizers) found be associated either or In conclusion, investigated do not seem play present sample depressive patients. Nevertheless, methodological size limitations allow definitive conclusions.