5-HTTLPR modulates antidepressant efficacy in depressed women

• DOI: 10.1097/ypg.0b013e32832cef0d
• Publication Date: 2009-07-01T07:26:38Z
• Authors: Florence Gressier; Elodie Bouaziz; Céline Verstuyft; Patrick Hardy; Laurent Becquemont; Emmanuelle Corruble
• Keywords: 5-HTTLPR; Depression; Citalopram; Serotonin reuptake inhibitor

As compared with the long variant (L), short (S) of functional polymorphic region serotonin transporter gene (5-HTTLPR) has been associated a lower antidepressant efficacy in major depression, but some replication studies have evidenced contradictory results. Sex differences may explain these results.One hundred and three inpatients (74 women 29 men) depressive episode were assessed prospectively for after 4 weeks treatment selective reuptake inhibitors (SSRI) non-SSRI drugs.As LL/LS, SS genotype 5-HTTLPR was depressed (79 vs. 50% responders, P = 0.035). This result shown both SSRI antidepressants. The logistic regression performed showed that response to related (odds ratio=0.15; 95% confidence interval=0.03-0.85; 0.03) not other variables. No effect found men.Despite low power, this study suggests significant on men, drugs. Further research is needed confirm investigate its underlying mechanisms.