Phenotypic characterization of Neisseria meningitidis strains isolated from invasive meningococcal disease in Brazil from 2002 to 2017

• DOI: 10.1099/acmi.0.000079
• Publication Date: 2019-12-10T17:12:54Z
• Authors: Maria Cecília Gorla; Angela Pires Brandao; Juliana Maira Wat...; Camile de Moraes; Gabriela Pereira; Ana Paula Lemos
• Keywords: Neisseriaceae; Case fatality rate

Invasive meningococcal disease (IMD) has a high rate of fatality and may cause severe clinical sequelae. Over the years, epidemiology IMD changed significantly in various regions world, laboratory surveillance this is important for mapping epidemiologic changes.To perform phenotypic characterization Neisseria meningitidis strains isolated from invasive Brazil 2002 to 2017, as complementation data obtained period 1990-2001.In total, 8,689 isolates sent Adolfo Lutz Institute confirmed N. by conventional methods were serogrouped slide agglutination against MenA, MenB, MenC, MenE, MenW, MenX, MenY MenZ; serotyped serosubtyped whole-cell dot-blotting assay with monoclonal antibodies.The all Brazil, southeast region was responsible largest number (57.2 %). Overall, total sample (n=8,689) represented serogroups C (n=4,729; 54.4 %), B (n=3,313; 38.1 W (n=423; 4.9 Y (n=203; 2.3 X (n=5; 0.1 %) others (n=16; 0.2 A shift prevalence observed 2006, when serogroup became most prevalent (65.5 surpassing (21.9 The main phenotypes C:23:P1.14-6; B:4,7:P1.19,15; W:2a:P1.5 W:2a:P1.5,2.The show an change distribution serogroups, serotypes subtypes occurring during 2002-2017. continuous laboratory-based provides robust information implement appropriate strategies control.