Comparative genomics analysis of six Cutibacterium acnes strains isolated from contaminated platelet concentrates

• DOI: 10.1099/acmi.0.000938.v3
• Publication Date: 2025-04-08T15:07:54Z
• Authors: Annika Flint; Dilini Kumaran; Kelly Weedmark; Franco Pagotto; Sandra Ramirez-Arcos

Cutibacterium acnes is a bacterial skin commensal that often isolated during routine testing of blood products like platelet concentrates (PCs). Due to the slow-growing nature this bacterium in culture media, C. contaminated PCs are transfused into vulnerable patients before retrieval these units can be initiated. This study aimed at obtaining whole-genome sequence six isolates derived from PCs, comparing and assessing their genetic backgrounds. Furthermore, whole genomes PC were compared clinical obtained different sites types infection. The results indicate assessed belong four phylotypes, namely IA, IB, II III. Whole-genome comparisons identified differences virulence profiles provide foundation for future studies evaluating risk transfusion by determining whether expression factors impacted storage environment.