Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes

• DOI: 10.1099/jmm.0.021089-0
• Publication Date: 2010-06-18T02:11:23Z
• Authors: Cleiton S. Santos; Júlio O. Macedo; Mauricio Bandeira; Adenizar D. Chaga...; Alan J. A. McBride; Flávia W. C. McBride; Mitermayer G. Reis; Daniel A. Athanazio
• Keywords: Direct agglutination test; Leptospira interrogans; Subclinical infection; Strain (injury)

The mouse disease model has the advantage of a broad array immunological and genetic tools available for basic research. Some studies on transgenic and/or mutant strains as models experimental leptospirosis have been reported; however, wider use such is hampered by poor understanding outcome leptospiral infection among different available. Here, virulent strain Leptospira interrogans serogroup Icterohaemorrhagiae Cop was studied in four commonly used wild-type strains: A, CBA, BALB/c C57BL/6. end points evaluated this study were survival, presence kidney lesions, load samples, microscopic agglutination test titre anti-leptospiral IgG antibody levels. As expected, none susceptible to lethal leptospirosis. However, these developed specific pathologies associated with sublethal A C57BL/6 exhibited high samples CBA severe inflammatory whilst proved be most resistant subclinical