Changes in antimicrobial susceptibility and major clones of Acinetobacter calcoaceticus–baumannii complex isolates from a single hospital in Korea over 7 years

• DOI: 10.1099/jmm.0.033852-0
• Publication Date: 2011-08-19T04:39:16Z
• Authors: Young Kyoung Park; Sook-In Jung; Kyong-Hwa Park; Dae Hun Kim; Ji Young Choi; Su Hwan Kim; Kwan Soo Ko
• Keywords: Acinetobacter baumannii; Carbapenem; Acinetobacter calcoaceticus; Polymyxin; Cefepime

Acinetobacter species have emerged as opportunistic nosocomial pathogens in intensive care units. Epidemic spread and outbreaks of multidrug-resistant or carbapenem-resistant baumannii infections been described worldwide. Species distribution, antimicrobial resistance genotypes were investigated for isolates collected from a single institution Korea over 7 years. Two hundred eighty-seven patients with bloodstream one Korean hospital 2003 to 2010. Most them belonged the calcoaceticus-baumannii complex (94.4 %). The most frequently isolated was A. (44.2 %), followed by nosocomialis (formerly genomic 13TU) (34.1 proportion increased significantly 2008 2010 (40.4 50.0 From 2008, imipenem meropenem rates compared 2003-2007 (12.9 % 20.5 %, respectively, 41.4 41.5 respectively). An carbapenem rate between two periods identified more clearly amongst isolates. Polymyxin-resistant 2008-2010, despite availability few increase might be due substitution main clones. Although ST92 ST69 prevalent clones (47.8 15.9 respectively), ST75 ST138 had 2008-2010 (39.7 25.9 showed moderate carbapenems, resistant carbapenems. All isolates, but only isolate, contained bla(OXA-23-like) gene. Increased expansion specific