Characterization of rotavirus causing acute diarrhoea in children in Kathmandu, Nepal, showing the dominance of serotype G12

• DOI: 10.1099/jmm.0.048124-0
• Publication Date: 2012-10-05T03:21:12Z
• Authors: Shamshul Ansari; Jeevan Bahadur Sh...; Basista Prasad Rijal; Keshab Parajuli; Shyam Kumar Mishra; Rajan Kumar Dahal; Shovita Shrestha; Sarmila Tandukar; Raina Chaudhary; Hari Prasad Kattel; Amul Basnet; Bharat Mani Pokhrel
• Keywords: Acute diarrhea; Under-five; Acute gastroenteritis

Diarrhoeal diseases are a major problem in developing countries. Though precise data on childhood mortality associated with diarrhoeal Nepal not available, it has been estimated that approximately 25 % of child deaths disease, particularly acute diarrhoea. The purpose this study was to assess the incidence rotavirus causing diarrhoea children less than 5 years age. A total 525 children’s hospital Kathmandu, Nepal, were enrolled between April and September 2011. due 25.9 (136/525) as determined by ELISA. percentage rotavirus-infected males higher (64.5 %) females (35.5 %). frequency cases 2 age, among which majority (80.2 6 24 months old (P<0.01). Genotypic characterization RT-PCR revealed serotype G12 represented 55.9 P-types either P[6], P[4] or P[8]. Further this, eight G/P combinations identified, G12P[6] being most common strain type prevalence rate 46.4 %. aim find out genotypes children.