Prevalence, seasonality and severity of disease caused by pathogenic Escherichia coli in children with diarrhoea in Bolivia

• DOI: 10.1099/jmm.0.060798-0
• Publication Date: 2013-07-13T05:36:06Z
• Authors: Lucia Gonzales; Enrique Joffre; Rosario Rivera; Åsa Sjöling; Ann-Mari Svennerholm; Volga Iñiguez
• Keywords: Sulfamethoxazole; Trimethoprim

The prevalence of infection caused by different categories diarrhoeagenic E. coli (DEC) strains, including enteroaggregative (EAEC), enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroinvasive (EIEC) and enterohaemorrhagic (EHEC) , in children who suffered from diarrhoea ( n = 3943) or did not have 1026) were analysed two areas Bolivia over a period 4 years. We also the seasonality DEC infections severity with compared antibiotic resistance strains isolated without diarrhoea. Stool samples for presence culturing followed PCR. most prevalent were: EAEC (11.2 %); ETEC (6.6 EPEC (5.8 EIEC EHEC (<1 %). significantly more often cases (21.6 %) than controls (17.6 %; P 0.002). number associated EAEC, peaked Bolivian winter (April–September), although proportion DEC-positive stool was higher during warm rainy season (October–March). High levels detected among strains. In particular, to tetracycline sulfamethoxazole–trimethoprim individuals controls. disease infected varied mild severe diarrhoea, differ between categories. ETEC, are commonly found may cause children.