Invasive multidrug-resistant non-typhoidal Salmonella infections in Africa: zoonotic or anthroponotic transmission?

Salmonella enterica
DOI: 10.1099/jmm.0.46375-0 Publication Date: 2006-04-03T21:48:02Z
ABSTRACT
In Africa, multidrug-resistant non-typhoidal salmonellae (NTS) are one of the leading causes morbidity and high mortality in children under 5 years age, second importance only to pneumococcal disease. The authors studied NTS isolates from paediatric admissions at two hospitals Nairobi, Kenya, followed index cases their homes, where rectal swabs stools parents siblings, animals close contact, were obtained. majority obtained Salmonella enterica serotype Typhimurium (106 out 193; 54.9%) Enteritidis (64; 33.2%), a significant proportion (34.2%) which multiply resistant three or more antibiotics, including ampicillin, tetracycline, cotrimoxazole chloramphenicol. Only 23.4% fully susceptible all 10 antibiotics tested. Of 32 contacts (nine adults 23 children) homes cases, 21 (65.6%) similar by antibiotic-susceptibility profiles plasmid content, XbaI- SpeI-digested chromosomal DNA patterns indistinguishable those corresponding cases. 180 (1.7%) samples environmental sources, animals, soil, sewers food, contained matching carriage an asymptomatic population was represented 6.9% human 27 127 sampled. This carriers may represent important reservoir that would play role epidemiology community-acquired bacteraemia children.
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