Pangenome of Acinetobacter baumannii uncovers two groups of genomes, one of them with genes involved in CRISPR/Cas defence systems associated with the absence of plasmids and exclusive genes for biofilm formation

• DOI: 10.1099/mgen.0.000309
• Publication Date: 2019-10-18T17:12:17Z
• Authors: Eugenio L. Mangas; Alejandro Rubio; Rocío Álvarez-Marín; Gema Labrador-Her...; Jerónimo Pachón; María Eugenia Pac...; Federico Divina; Antonio J. Pérez-...
• Keywords: Acinetobacter baumannii

Acinetobacter baumannii is an opportunistic bacterium that causes hospital-acquired infections with a high mortality and morbidity, since there are strains resistant to virtually any kind of antibiotic. The chase find novel strategies fight against this microbe can be favoured by knowledge the complete catalogue genes species, their relationship specific characteristics different isolates. In work, we performed genomics analysis almost 2500 strains. Two groups genomes were found based on number shared genes. One these rarely has plasmids, bears clustered regularly interspaced short palindromic repeat (CRISPR) sequences, in addition CRISPR-associated (cas genes) or restriction-modification system This fact strongly supports lack plasmids. Furthermore, scarce plasmids group also bear CRISPR specifically contain involved prokaryotic toxin-antitoxin systems could either act as still little known type IV precursors other CRISPR/Cas systems. addition, limited set present new cas9-like gene, which may complement cas inhibiting entrance into bacteria. Finally, exclusive biofilm formation, would connect biogenesis bacterial resistance structures.