Lipopolysaccharide core type diversity in the Escherichia coli species in association with phylogeny, virulence gene repertoire and distribution of type VI secretion systems

• DOI: 10.1099/mgen.0.000652
• Publication Date: 2021-09-29T15:21:08Z
• Authors: Sébastien O. Lecl...; Maxime Branger; David G. E. Smith; Pierre Germon
• Keywords: Pathogenicity island

Escherichia coli is a very versatile species for which diversity has been explored from various perspectives highlighting, example, phylogenetic groupings and pathovars, as well wide range of O serotypes. The highly variable O-antigen, the most external part lipopolysaccharide (LPS) component outer membrane E. , linked to innermost lipid A through core region LPS five different structures, denominated K-12, R1, R2, R3 R4, have characterized so far. aim present study was analyse prevalence these types in explore their distribution groups relationship with virulence gene repertoire. Results indicated an uneven between phylogroups, phylogroup strains being diverse terms types, while phylogroups B1, D E were dominated by type, B2 C R1 type. Strains carrying LEE operon mostly type whatever while, within B2, K-12 all belonged complex STc131, one major clones extraintestinal pathogenic (ExPEC) strains. origin this discussed but remains be fully explained, consequences specific on wider aspects bacterial phenotype.