Prophages encoding human immune evasion cluster genes are enriched in Staphylococcus aureus isolated from chronic rhinosinusitis patients with nasal polyps

• DOI: 10.1099/mgen.0.000726
• Publication Date: 2021-12-15T13:17:40Z
• Authors: Roshan Nepal; Ghais Houtak; Gohar Shaghayegh; George Bouras; Keith Shearwin; Alkis James Psaltis; Peter-John Wormald; Sarah Vreugde
• Keywords: Prophage; Lysogenic cycle

Prophages affect bacterial fitness on multiple levels. These include infectivity, toxin secretion, virulence regulation, surface modification, immune stimulation and evasion microbiome competition. Lysogenic conversion arms bacteria with novel accessory functions thereby increasing fitness, host adaptation persistence, antibiotic resistance. properties allow the to occupy a niche long term can contribute chronic infections inflammation such as rhinosinusitis (CRS). In this study, we aimed identify characterize prophages present in