Genomic analysis of the initial dissemination of carbapenem-resistant Klebsiella pneumoniae clones in a tertiary hospital

• DOI: 10.1099/mgen.0.001032
• Publication Date: 2023-06-05T14:17:13Z
• Authors: Neris Garcia-Gonz...; Begoña Fuster; Nuria Tormo; Carme Salvador; Concepcion Gimeno; Fernando Gonzalez...
• Keywords: Carbapenem

Carbapenem-resistant Klebsiella pneumoniae is a major cause of hospital-acquired infections and the fastest-growing pathogen in Europe. Carbapenem resistance was detected at Consorcio Hospital General Universitario de Valencia (CHGUV) early 2015, there has been significant increase carbapenem-resistant isolates since then. In this study, we collected from hospital during period (from 2015 to 2019) studied how K. emerged spread hospital. A total 225 were subjected whole-genome sequencing with Illumina NextSeq. We characterized by identifying lineages antimicrobial genes plasmids, especially those related reduced carbapenem susceptibility. Our findings show that initial emergence dissemination CHGUV occurred short 1 year. Furthermore, it complex, involving six different types ST307, ST11, ST101 ST437, resistance-determinant factors, including OXA-48, NDM-1, NDM-23 DHA-1, plasmids.