The intestinal proteome of diabetic and control children is enriched with different microbial and host proteins

• DOI: 10.1099/mic.0.000412
• Publication Date: 2016-12-17T00:07:40Z
• Authors: Elsa Pinto; Marisol Anselmo; Manuela Calha; Andrew Bottrill; Isabel Duarte; Peter W Andrew; Maria L Faleiro
• Keywords: Proteome

In this study, the intestinal microbial proteome of children with established type 1 diabetes (T1D) was compared healthy (Control) aim to identify differences in activity microbiota that not only will contribute a deeper knowledge functionality gut these but also may provide new approaches improve control disease. Faecal protein extracts collected from three T1D (aged 9.3±0.6 years) and Control 9.3±1.5 were analysed using combination 2D gel electrophoresis spectral counting. The results evidenced markedly between Control. enriched proteins clostridial cluster XVa IV Bacteroides. contrast, bifidobacterial proteins. both groups, moonlight function observed. Human distinguished two groups depleted exocrine pancreatic enzymes.