Phenotype switching affects biofilm formation by Candida parapsilosis

• DOI: 10.1099/mic.0.27739-0
• Publication Date: 2005-04-07T18:18:56Z
• Authors: Sean F. Laffey; Geraldine Butler
• Keywords: Phenotypic switching; Candida parapsilosis

Generation of biofilms by the pathogenic yeast Candida parapsilosis is correlated closely with disease. The phenomenon phenotype switching in 20 isolates C. was examined and relationship biofilm development investigated. Four stable heritable phenotypes were identified – crepe, concentric, smooth crater. Cells from crepe concentric are almost entirely pseudohyphal, whilst cells crater mostly yeast-like. pseudohyphae approximately 45 % wider than those cells. cell size smaller other three phenotypes. On polystyrene surfaces, generates up to twofold more Smooth generate least biofilm. Concentric also invade agar surfaces phenotypes, do not at all. phenotype, however, grows significantly faster others. quorum-sensing molecule farnesol inhibits formation