The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans

• DOI: 10.1099/mic.0.28038-0
• Publication Date: 2005-08-03T21:13:13Z
• Authors: Federico Navarro-...; Blanca Eisman; Sonia M. Fiuza; César Nombela; Jesús Pla
• Keywords: Osmotic shock; Osmotic pressure; Osmotic concentration

Candida albicans is an opportunistic pathogen that has adapted to live and grow in the human body as its natural environment. Under these conditions, this fungus faces numerous challenges, including oxidative, osmotic enzymic processes may damage external internal structures. In view of key role MAP kinase signalling pathways physiology C. , effect agents mimicking vivo environmental conditions on activation p42-44 kinases been analysed. It found Mkc1p phosphorylated presence oxidative stress, changes pressure, cell wall a decrease growth temperature. This phosphorylation dependent Pkc1p, indicating both proteins operate same pathway . some stimuli, required Hog1p, high osmolarity glycerol (HOG) pathway. suggests existence new regulatory role, at least under for yeast.