The neonatal Fc receptor does not modulate hepatitis C virus neutralization

• DOI: 10.1099/vir.0.000060
• Publication Date: 2015-01-23T01:32:34Z
• Authors: Anthony Morel; Christophe Passot; Christophe Arnoult; Amélie Dumans; Elodie Beaumont; Valérie Gouilleux...; Philippe Roingeard; Emmanuelle Blanchard
• Keywords: 0301 basic medicine; [SDV]Life Sciences [q-bio]; Histocompatibility Antigens Class I; Infant, Newborn; 610; Hepacivirus; Receptors, Fc; Antibodies, Viral; Antibodies, Neutralizing; 3. Good health; [SDV] Life Sciences [q-bio]; 03 medical and health sciences; Neutralization Tests; Humans

The neonatal Fc receptor (FcRn) is the only receptor known to be able to transport IgG across cell barriers and may therefore modulate virus infection. FcRn is expressed efficiently in hepatocytes. We therefore investigated the possible involvement of an FcRn-dependent mechanism in hepatitis C virus (HCV) neutralization. Our study, in both HCV pseudoparticles and HCV in cell-culture models, showed that FcRn was not involved in the intracellular neutralization of HCV, in contrast to the situation observed for influenza A virus.