Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection

• DOI: 10.1099/vir.0.027052-0
• Publication Date: 2010-12-10T04:02:45Z
• Authors: S. Bacsa; G. Karasneh; S. Dosa; J. Liu; T. Valyi-Nagy; D. Shukla
• Keywords: Syndecan 1; HSL and HSV; Core protein

Herpes simplex virus type 1 (HSV-1) is an important human pathogen and a leading cause of infectious blindness in the developed world. HSV-1 exploits heparan sulfate proteoglycans (HSPG) for attachment to cells. While significance sulphate (HS) moieties infection well established, role specific proteoglycan core proteins process remains poorly understood. The objective this study was assess roles syndecan-1 syndecan-2 infection, both which are expressed by many target cell types. Our results demonstrate that gene silencing RNA interference reduces entry, plaque formation facilitates survival. Furthermore, increases protein synthesis resultant increase surface expression HS. observations suggest changes levels may be related active viral infection. Taken together, our findings provide new insights into HSPG functions during entry spread.