Local immune response to respiratory syncytial virus infection is diminished in senescence-accelerated mice

• DOI: 10.1099/vir.0.83089-0
• Publication Date: 2007-08-13T19:28:15Z
• Authors: Beixing Liu; Yoshinobu Kimura
• Keywords: Adoptive Cell Transfer

The effect of ageing on the local defence system against respiratory syncytial virus (RSV) infection was investigated using an aged mouse model senescence-accelerated (SAM) strain P1. Following intranasal with RSV, SAM-P1 mice showed a marked loss in weight, elevated growth lungs and prolonged shedding. increased susceptibility to RSV associated mainly diminished cellular immunity by virus-specific cytotoxic T lymphocytes natural killer cells. deficiency immune responses due lack clonal expansion CD4 + CD8 lymphocytes, together imbalance T-helper type 1 (Th1)/Th2 cytokine production tract, including lungs. Furthermore, IgA antibody restrained. Prolonged loading caused massive infiltration CD16 /32 inflammatory cells, which one factor responsible for severe pneumonia. adoptive transfer immune-competent spleen cells achieved appreciable protection challenge infection. These results suggested that age-related dysfunction, especially defects responses, accounts morbidity mortality elderly.