Reduced Glucose Sensation Can Increase the Fitness ofSaccharomyces cerevisiaeLacking Mitochondrial DNA

• DOI: 10.1101/024331
• Publication Date: 2015-08-11T05:02:28Z
• Authors: Emel Akdoğan; Mehmet Tardu; Görkem Garipler; Gülkız Baytek; İ. Halil Kavaklı; Cory D. Dunn
• Keywords: Sensation

Abstract Damage to the mitochondrial genome (mtDNA) can lead diseases for which there are no clearly effective treatments. Since function and biogenesis controlled by nutrient environment of cell, it is possible that perturbation conserved, nutrient-sensing pathways may successfully treat disease. We found restricting glucose or otherwise reducing activity protein kinase A (PKA) pathway improved proliferation Saccharomyces cerevisiae cells lacking mtDNA transcriptional response loss reduced in with diminished PKA activity. have excluded many proteins from being individually responsible benefits provided inhibition, we robust import polytopic membrane be required order without receive full reduction. Finally, discovered transcription genes involved arginine biosynthesis aromatic amino acid catabolism altered after damage. Our results highlight potential importance detection availability on outcome dysfunction.