Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

• DOI: 10.1101/030288
• Publication Date: 2015-11-04T06:12:14Z
• Authors: Padhraig Gormley; Verneri Anttila; Bendik S Winsvold; Priit Palta; Tonu Esko; Tune H. Pers; Kai-How Farh; Ester Cuenca-Leon; Mikko Muona; Nicholas A Furlotte; Tobias Kurth; Andres Ingason; George McMahon; Lannie Ligthart; Gisela M Terwindt; Mikko Kallela; Tobias M Freilinger; Caroline Ran; Scott G Gordon; Anine H Stam; Stacy Steinberg; Guntram Borck; Markku Koiranen; Lydia Quaye; Hieab HH Adams; Terho Lehtimäki; Antti-Pekka Sarin; Juho Wedenoja; David A Hinds; Julie E Buring; Markus Schürks; Paul M Ridker; Maria Gudlaug Hra...; Hreinn Stefansson; Susan M Ring; Jouke-Jan Hottenga; Brenda WJH Penninx; Markus Färkkilä; Ville Artto; Mari Kaunisto; Salli Vepsäläinen; Rainer Malik; Andrew C Heath; Pamela A F Madden; Nicholas G Martin; Grant W Montgomery; Eija Hämäläinen; Hailiang Huang; Andrea E Byrnes; Lude Franke; Jie Huang; Evie Stergiakouli; Phil H Lee; Cynthia Sandor; Caleb Webber; Zameel Cader; Bertram Muller-My...; Stefan Schreiber; Thomas Meitinger; Johan G Eriksson; Veikko Salomaa; Kauko Heikkilä; Elizabeth Loehrer; Andre G Uitterlinden; Albert Hofman; Cornelia M van Duijn; Lynn Cherkas; Linda M. Pedersen; Audun Stubhaug; Christopher S Nie...; Minna Männikkö; Evelin Mihailov; Lili Milani; Hartmut Göbel; Ann-Louise Esserlind; Anne Francke Chri...; Thomas Folkmann H...; Thomas Werge; Jaakko Kaprio; Arpo J Aromaa; Olli Raitakari; M Arfan Ikram; Tim Spector; Marjo-Riitta Järv...; Andres Metspalu; Christian Kubisch; David P Strachan; Michel D Ferrari; Andrea C Belin; Martin Dichgans; Maija Wessman; Arn MJM van den M...; John-Anker Zwart; Dorret I Boomsma; George Davey Smith; Kari Stefansson; Nicholas Eriksson; Mark J Daly; Benjamin M Neale; Jes Olesen; Daniel I. Chasman; Dale R Nyholt; Aarno Palotie
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Abstract Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine disease of vascular dysfunction, or result neuronal dysfunction with secondary changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated migraine. To identify new susceptibility loci, we performed the largest genetic study to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies. We 45 single nucleotide polymorphisms (SNPs) significantly risk ( P < 5 × 10 −8 ) that map 38 distinct genomic including 28 not previously reported first locus on chromosome X. Furthermore, subset analysis for without aura (MO) seven same as full sample, whereas no reached genome-wide significance (MA) subset. In subsequent computational analyzes, showed enrichment genes expressed smooth muscle tissues, consistent predominant theory highlights etiologies.