A descending pathway facilitates undulatory wave propagation inCaenorhabditis elegansthrough gap junctions

• DOI: 10.1101/131490
• Publication Date: 2017-06-18T05:10:11Z
• Authors: Tianqi Xu; Jing Huo; Shuai Shao; Michelle Po; Taizo Kawano; Yangning Lu; Min Wu; Mei Zhen; Quan Wen
• Keywords: Electrical Synapses; Biological neural network

Descending signals from the brain play critical roles in controlling and modulating locomotion kinematics. In Caenorhabditis elegans nervous system, descending AVB premotor interneurons exclusively form gap junctions with B-type motor neurons that drive forward locomotion. We combined genetic analysis, optogenetic manipulation, computational modeling to elucidate function of AVB-B during First, we found some generated intrinsic rhythmic activity, constituting distributed central pattern generators. Second, drove bifurcation neuron dynamics, triggering their transition stationary oscillatory activity. Third, proprioceptive couplings between neighboring entrained frequency body oscillators, forcing coherent propagation bending waves. Despite substantial anatomical differences worm circuit those higher model organisms, uncovered converging principles govern coordinated Significance Statement A deep understanding neural basis behavior must integrate neuromuscular mechanosensory feedback, as well global command signals, predict behavioral dynamics. Here, report on an integrative approach defining logic underlying C. elegans. Our experimental analysis revealed (1) could oscillators; (2) inputs work synergistically facilitate sequential activation activities, allowing waves propagate efficiently along body. thus represents a key step towards view animal