Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation

• DOI: 10.1101/2020.02.05.934463
• Publication Date: 2020-02-06T01:35:40Z
• Authors: Luís F. Ribeiro; Tatiana Catarino; Mário Carvalho; Sandra D. Santos; Luísa Cortes; Patricio O. Opazo; Lyn Rosenbrier Ri...; Daniel Choquet; José A. Esteban; João Peça; Ana Luísa Carvalho
• Keywords: Long-term depression

Abstract The ability of animals to store and retrieve food caches in the wild requires integration biological signals hunger, satiety memory. role ghrelin regulating feeding memory makes receptors an important target shape required cellular molecular responses. We investigated effects high ligand-independent activity receptor on physiology excitatory synapses. Blocking this type produced a decrease synaptic content AMPA hippocampal neurons reduction GluA1 phosphorylation at Ser845. Impaired constitutive from increased surface diffusion impaired delivery mediated by chemical long-term potentiation. These observations support for trafficking under basal conditions plasticity. Accordingly, we found that blocking impairs spatial recognition Impact statement This work uncovers memory, regulation levels receptors, their mobility Underscoring importance deciphering physiological activity, inverse agonism is now being considered as therapy treat alcohol use disorder.