Clinical characteristics of 2019 novel coronavirus infection in China

• DOI: 10.1101/2020.02.06.20020974
• Publication Date: 2020-02-09T15:24:15Z
• Authors: Wei-jie Guan; Zheng-yi Ni; Yu Hu; Wen-hua Liang; Chun-quan Ou; Jian-xing He; Lei Liu; Hong Shan; Chun-liang Lei; David S.C. Hui; Bin Du; Lan-juan Li; Guang Zeng; Kwok-Yung Yuen; Ru-chong Chen; Chun-li Tang; Tao Wang; Ping-yan Chen; Jie Xiang; Shi-yue Li; Jin-lin Wang; Zi-jing Liang; Yi-xiang Peng; Li Wei; Yong Liu; Ya-hua Hu; Peng Peng; Jian-ming Wang; Ji-yang Liu; Zhong Chen; Gang Li; Zhi-jian Zheng; Shao-qin Qiu; Jie Luo; Chang-jiang Ye; Shao-yong Zhu; Nan-shan Zhong
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Abstract Background Since December 2019, acute respiratory disease (ARD) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought delineate the clinical characteristics of these cases. Methods extracted data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD from 552 hospitals 31 provinces/provincial municipalities through January 29 th , 2020. Results The median age was 47.0 years, 41.90% were females. Only 1.18% had a direct contact wildlife, whereas 31.30% been 71.80% contacted people Wuhan. Fever (87.9%) cough (67.7%) most common symptoms. Diarrhea is uncommon. incubation period 3.0 days (range, 0 24.0 days). On admission, ground-glass opacity typical radiological finding chest computed tomography (50.00%). Significantly more severe cases diagnosed by symptoms plus reverse-transcriptase polymerase-chain-reaction without abnormal findings than non-severe (23.87% vs. 5.20%, P <0.001). Lymphopenia observed 82.1% patients. 55 (5.00%) admitted intensive care unit 15 (1.36%) succumbed. Severe pneumonia independently associated either admission unit, mechanical ventilation, or death multivariate competing-risk model (sub-distribution hazards ratio, 9.80; 95% confidence interval, 4.06 23.67). Conclusions epidemic spreads human-to-human transmission. Normal radiologic are present among some infection. severity (including oxygen saturation, rate, blood leukocyte/lymphocyte count X-ray/CT manifestations) predict poor outcomes.