Verbal Communication using Intracortical Signals in a Completely Locked In-Patient

• DOI: 10.1101/2020.06.10.20122408
• Publication Date: 2020-06-12T14:19:42Z
• Authors: Ujwal Chaudhary; Ioannis Vlachos; Jonas B. Zimmermann; Arnau Espinosa; Alessandro Tonin; Andres Jaramillo-...; Majid Khalili-Ardali; Helge Topka; Jens Lehmberg; Gerhard M. Friehs; Alain Woodtli; John P. Donoghue; Niels Birbaumer
• Keywords: 0301 basic medicine; 03 medical and health sciences

Abstract Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means communication. While others have evaluated in people remaining muscle control, to the best our knowledge, it is not known whether neural-based remains possible a completely locked-in state (CLIS). With consent approval participant, family, legal authority for this study, two 64 microelectrode arrays were implanted supplementary primary cortex CLIS patient ALS. The modulated neural firing rates based on auditory feedback, he used strategy select letters one at time form words phrases communicate his needs experiences. This case study provides novel evidence that brain-based volitional even state.