Maternal blood lipidomics analyses link critical metabolic pathways associated with severe preeclampsia

• DOI: 10.1101/2020.07.05.20145292
• Publication Date: 2020-07-08T16:25:17Z
• Authors: Yu Liu; Bing He; Mano R Maurya; Paula Benny; Cameron Lassiter; Hui Li; Shankar Subraminiam; Lana X. Garmire
• Keywords: Lipidome; Lysophosphatidylethanolamine; Dyslipidemia

ABSTRACT Preeclampsia is a pregnancy specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. To reveal the relationship between lipids preeclampsia, we conduct lipidomic profiling maternal serums 44 severe preeclamptic healthy pregnancies from multi-ethnic cohort in Hawaii. Correlation network analysis shows that oxidized phospholipids (OxPLs) have increased inter-correlations connections while other lipids, including triacylglycerols (TAGs), reduced correlations connections. Thirty-one lipid species various classes demonstrate predominantly reductions causal relationships with preeclampsia. They include phosphatidylglycerol (PG), TAG, diacylglycerol (DAG), phosphatidylcholine (PC), cholesterol esters (CE), phosphatidylethanolamine (PE), sphingomyelin (SM), ceramides (Cer-NS), hexosyl (HexCer-NS), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), free fatty acid (FFA). Many these are also selected as important features linear discriminant (LDA) classifier high predictive accuracy (F-1 statistic 0.941 balanced 0.88), indicating their potential to serve biomarkers for Our study supports hypothesis phospholipid (PL) centered, dysregulated metabolic atlas. That is, preeclampsia may be originated hypoxia, which induces accumulation OxPLs through oxidative stress whereas reduces many (eg. PCs, TAGs ceramides). These molecular changes coherently lead biological functions, such insulin signaling inflammation/infections. Moreover, responsible comorbidity gestational diabetes, clinically known risk factor