Past SARS-CoV-2 infection elicits a strong immune response after a single vaccine dose

• DOI: 10.1101/2021.03.14.21253039
• Publication Date: 2021-03-24T17:40:11Z
• Authors: Rossana Elena Chahla; Rodrigo Hernán To...; Silvia Inés Cazorla; Diego Ploper; Esteban Vera Ping...; Mónica Aguilar López; Patricia Aznar; Malena Alcorta; Eva María del Mar...; Agustín Stagnetto; César Luís Ávila; Carolina Maldonad...; Sergio Benjamín S...; Dar Heinze; Silvia Adriana Na...; Conrado Llapur; Dardo Costas; Isolina Flores; Gabriela Apfelbaum; Raúl Mostoslavsky; Gustavo Mostoslavsky; Gabriela Perdigón; Rosana Nieves Chehín
• Keywords: Antibody response; Antibody titer; Booster dose

Abstract We hypothesized that in individuals with previous SARS-CoV-2 infection, the first vaccine dose would work as a booster, eliciting faster and more intense immune response. herein describe antibody responses to second doses of Gam-COVID-Vac (SPUTNIK V) health personnel Tucumán, Argentina, COVID-19 compared it uninfected personnel. Individuals anti-SARS-CoV-2 titers at baseline showed significantly higher than people no prior history disease (p <0.0001), those registered after control group, representing clear secondary This suggests single SPUTNIK V for infection could contribute better use available doses. One-Sentence Summary First subjects COVID19 elicits response two