Aberrant Functional Connectivity between Reward and Inhibitory Control Networks in Pre-Adolescent Binge Eating Disorder

• DOI: 10.1101/2021.10.06.463386
• Publication Date: 2021-10-09T02:15:53Z
• Authors: Stuart B. Murray; Celina Alba; Christina J. Duval; Jason M. Nagata; Ryan P. Cabeen; Darrin J. Lee; Arthur W. Toga; Steven J. Siegel; Kay Jann
• Keywords: Orbitofrontal cortex; Reward system; Dorsolateral prefrontal cortex; Inhibitory control; Cingulate cortex

Abstract Background Behavioral features of binge eating disorder (BED) suggest abnormalities in reward and inhibitory control. Studies adult populations functional control networks. Despite behavioral markers often developing children, the neurobiology pediatric BED remains unstudied. Methods 58 pre-adolescent children (aged 9-10-years) with 66 age, BMI developmentally-matched were extracted from 3.0 baseline (Year 0) release Adolescent Brain Cognitive Development (ABCD) Study. We investigated group differences resting-state MRI (rs-fMRI) connectivity (FC) within between A seed-based approach was employed to assess nodes (orbitofrontal cortex, nucleus accumbens, amygdala) (dorsolateral prefrontal anterior cingulate cortex) networks via hypothesis-driven seed-to- seed analyses, secondary seed-to-voxel analyses. Results Our findings revealed reduced FC dlPFC amygdala, cortex orbitofrontal BED, relative gender, developmentally matched controls. These indicating aberrant corroborated by whole-brain Conclusions Early-onset may be characterized diffuse synergy cognitive networks, without perturbations respectively. The decreased capacity regulate a reward-driven pursuit hedonic foods, which is characteristic part, rest on this dysconnectivity