Booster dose of BNT162b2 in a CoronaVac primary vaccination protocol improves neutralization of SARS-CoV-2 Omicron variant

• DOI: 10.1101/2022.03.24.22272904
• Publication Date: 2022-03-26T00:40:28Z
• Authors: Guilherme R. F. C...; Nathalie Bonatti ...; Priscilla Soares ...; Camila Amormino C...; Sarah Vieira Cont...; Daniel Alvim Pena...; Jéssica Vieira de...; Thaís Bárbara de ...; Pedro Augusto Alves; Gabriel da Rocha ...; Jaquelline German...; Paula Rahal; Rafaella Fortini ...; Maurício L. Nogueira
• Keywords: Booster (rocketry); Booster dose

The emergence of the new SARS-CoV-2 Omicron variant, which is known to accumulate a huge number mutations when compared other variants, brought light concern about vaccine escape, especially from neutralization by antibodies induced vaccination. In this scenario, we evaluated impact on antibody induction, against booster dose BNT162b2 mRNA after CoronaVac primary vaccination scheme. percentage seroconverted individuals 30 and 60 days scheme was 17% 10%, respectively. After administration, seroconvertion rate increased 76.6%. mean titer in protocol decreased over time, but dose, 43.1 times, indicating positive combination serological immune response.