Epstein-Barr Virus DNAemia and Post-Transplant Lymphoproliferative Disorder in Pediatric Solid Organ Transplant Recipients

• DOI: 10.1101/2022.06.04.22275823
• Publication Date: 2022-06-07T01:30:22Z
• Authors: Yeh-Chung Chang; Rebecca R. Young; Alisha M. Mavis; Eileen T. Chambers; Sonya Kirmani; Matthew S. Kelly; Ibukunoluwa C. Kalu; Michael J. Smith; Debra J. Lugo
• Keywords: Post-transplant lymphoproliferative disorder; JC Virus

Abstract Background Pediatric solid organ transplant (SOT) recipients commonly have Epstein-Barr virus (EBV) DNAemia and are at risk of developing post-transplant lymphoproliferative disorder (PTLD). EBV has not been analyzed on a continuous scale in this population. Methods All children ≤ 18 years age who underwent SOT single center between January 1, 2007 July 31, 2018 were included retrospective study. Transplant episodes which PTLD occurred compared to without PTLD. Multivariable logistic regression was used identify factors associated with the development maximum height DNAemia. A Cox proportional hazards model calculate hazard ratios for time Results Of 275 total 294 episodes, there 14 Intestinal multivisceral strongly (p=0.002). Risk include donor recipient positive serologies (p=0.001) older (p=0.001). Maximum level significantly (p<0.0001). Every one log (log 10 ) increase more than doubling (HR: 2.18, 95% CI 1.19-3.99). Conclusions type pediatric recipients. High levels an increased