Seroreversion toChlamydia trachomatisPgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia

• DOI: 10.1101/2023.02.04.23285360
• Publication Date: 2023-02-08T02:40:16Z
• Authors: Christine Tedijanto; Solomon Aragie; Sarah Gwyn; Dionna M. Wittberg; Taye Zeru; Zerihun Tadesse; Ambahun Chernet; Isabel J.B. Thompson; Scott D. Nash; Thomas M. Lietman; Diana L. Martin; Jeremy D. Keenan; Benjamin F. Arnold
• Keywords: Male; 0301 basic medicine; Endemic Diseases; IgG; 610; Chlamydia trachomatis; Antibodies; Article; 03 medical and health sciences; Bacterial Proteins; antibody; Humans; Longitudinal Studies; Antigens; Child; Preschool; Trachoma; Bacterial; Infant; trachoma; 3. Good health; Immunoglobulin G; Female; Ethiopia; seroepidemiology

ABSTRACTMonitoring trachoma transmission with antibody data requires characterization of decay in IgG toChlamydia trachomatisantigens. In a three-year longitudinal cohort in a high transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 (95% CI: 1.6, 3.5) per 100 person-years.