CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence

• DOI: 10.1101/2023.02.14.528487
• Publication Date: 2023-02-15T20:25:18Z
• Authors: Taylor A. Heim; Ochapa Ibrahim; Ziyan Lin; Maria M. Steele; Tenny Mudianto; Amanda W Lund
• Keywords: 0301 basic medicine; 03 medical and health sciences; Article

Tissue resident memory T cells (TRM) provide important protection against infection, and yet the interstitial signals necessary for their formation persistence remain incompletely understood. Here we show that antigen-dependent induction of chemokine receptor, CXCR6, is a conserved requirement TRM in peripheral tissue after viral infection. CXCR6 was dispensable early accumulation antigen-specific CD8+ skin did not restrain exit. Single cell sequencing indicated CXCR6-/- were also competent to acquire transcriptional program residence but exhibited deficiency multiple pathways converged on survival metabolic memory. As such, increased rates apoptosis relative controls dermis, leading inefficient formation. expression may therefore represent common mechanism across non-lymphoid tissues inflammatory states increases probability long-term residence.