Surveillance ofNeisseria meningitidisCarriage Four Years After menACWY Vaccine Implementation in the Netherlands Reveals Decline in Vaccine-type and Rise in Genogroup E Circulation

• DOI: 10.1101/2023.02.24.23286220
• Publication Date: 2023-02-24T22:00:21Z
• Authors: Willem R. Miellet; Gerlinde Pluister; Meike Sikking; Marcia Tappel; Jurgen Karczewski; Linda J. Visser; Thijs Bosch; Krzysztof Trzciński; Rob Mariman
• Keywords: 0301 basic medicine; General Veterinary; General Immunology and Microbiology; Genotype; Public Health, Environmental and Occupational Health; Meningococcal Vaccines; menACWY vaccine; Neisseria meningitidis; Carriage surveillance; 3. Good health; Meningococcal Infections; Young Adult; 03 medical and health sciences; Infectious Diseases; Meningococcus; Journal Article; Molecular Medicine; Humans; Vaccines, Combined; Netherlands

ABSTRACTCarriage ofNeisseria meningitidisis an accepted endpoint in monitoring meningococcal vaccine effects. We applied molecular methods to assess the impact of menACWY vaccine implementation on meningococcal carriage and genogroup-specific prevalence in young adults in Fall of 2022, four years after the introduction of the tetravalent vaccine in the Netherlands. The overall carriage rate of genogroupable meningococci was not significantly different compared to the pre-menACWY cohort investigated in 2018 (20.8% or 125 of 601 versus 17.4.% or 52 of 299 individuals,p=0.25). Of n=125 carriers of genogroupable meningococci n=122 (97.6%) were positive for either vaccine-types menC, menW, menY or non-vaccine types menB, menE, menX and menZ, Compared with a pre-vaccine-implementation baseline, there was 3.8-fold reduction (p<0.001) in vaccine-type carriage rates and 9.0-fold increase (p<0.0001) in non-vaccine type menE prevalence. These findings imply that menACWY vaccination reduced circulation of vaccine-type meningococci, but lead to serogroup replacement in carriage.