Modelling 25-hydroxyvitamin D responses to different recommended daily intakes of vitamin D

• DOI: 10.1101/2023.06.16.23291505
• Publication Date: 2023-06-21T02:20:12Z
• Authors: Tao You; Nadda Muhamad; Joseph Jenner; Zhonghui Huang

AbstractThe reference nutrient intake for vitamin D in people aged ≥ 4 years is 10 μg/day in the UK, which contrasts with the recommended daily allowance of 15 μg/day for people aged 1-70 years in the USA. Using modelling of published data, we compared 95% confidence intervals for serum concentrations of 25-hydroxyvitamin D3(25(OH)D3) attained in response to these two doses. 97.5% of those taking 10 μg/day vs. 15 μg/day were predicted to attain circulating 25(OH)D concentrations >44 nmol/L vs. 50 nmol/L, respectively.