Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

• DOI: 10.1101/2023.08.04.552017
• Publication Date: 2023-08-07T17:00:17Z
• Authors: Richard Drexler; Robin Khatri; Thomas Sauvigny; Malte Mohme; Cecile L. Maire; Alice Ryba; Yahya Zghaibeh; Lasse Dührsen; Amanda Salviano-S...; Katrin Lamszus; Manfred Westphal; Jens Gempt; Annika K. Wefers; Julia Neumann; Helena Bode; Fabian Hausmann; Tobias B. Huber; Stefan Bonn; Kerstin Jütten; Daniel Delev; Katharina J. Weber; Patrick N. Harter; Julia Onken; Peter Vajkoczy; David Capper; Benedikt Wiestler; Michael Weller; Berend Snijder; Alicia Buck; Tobias Weiss; Michael B. Keough; Lijun Ni; Michelle Monje; Dana Silverbush; Volker Hovestadt; Mario L. Suvà; Saritha Krishna; Shawn L. Hervey-J...; Ulrich Schüller; Dieter H. Heiland; Sonja Hänzelmann; Franz L. Ricklefs
• Keywords: Vulnerability

Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is nascent. We present an epigenetically defined neural signature of glioblastoma that independently affects patients' survival. use reference signatures cells to deconvolve tumor DNA and classify samples into low- or high-neural tumors. High-neural glioblastomas exhibit hypomethylated CpG sites upregulation genes associated with synaptic integration. Single-cell transcriptomic analysis reveals high abundance stem cell-like malignant classified oligodendrocyte precursor glioblastoma. engender neuron-to-glioma synapse formation