3Dmapper: A Command Line Tool For BioBank-scale Mapping Of Variants To Protein Structures
0303 health sciences
Proteins
Genomics
Genòmica
Applications Note
03 medical and health sciences
Genetic coding variants
Simulació per ordinador
Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
Mutations in protein-coding regions
3Dmapper
Software
Biological Specimen Banks
DOI:
10.1101/2023.09.01.555502
Publication Date:
2023-09-05T08:20:10Z
AUTHORS (5)
ABSTRACT
ABSTRACTThe interpretation of genomic data is crucial to understand the molecular mechanisms of biological processes. Protein structures play a vital role in facilitating this interpretation by providing functional context to genetic coding variants. However, mapping genes to proteins is a tedious and error-prone task due to inconsistencies in data formats. Over the past two decades, numerous tools and databases have been developed to automatically map annotated positions and variants to protein structures. However, most of these tools are web-based and not well-suited for large-scale genomic data analysis. To address this issue, we introduce 3Dmapper, a standalone command-line tool developed in Python and R. It systematically maps annotated protein positions and variants to protein structures, providing a solution that is both efficient and reliable. 3Dmapper is freely available on GitHub athttps://github.com/vicruiser/3Dmapper.
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