Human adolescent brain similarity development is different for paralimbic versus neocortical zones

• DOI: 10.1101/2023.09.17.558126
• Publication Date: 2023-09-18T00:50:25Z
• Authors: Lena Dorfschmidt; František Váša; Simon R. White; Rafael Romero-García; Manfred G. Kitzbi...; Aaron Alexander-B...; Matthew Cieslak; Kahini Mehta; Theodore D. Satte...; ; Richard A.I. Beth...; Jakob Seidlitz; Petra E. Vértes; Edward T. Bullmore
• Keywords: Posterior cingulate; Human brain; Similarity (geometry); Cingulate cortex

Abstract Adolescent development of human brain structural and functional networks is increasingly recognised as fundamental to emergence typical atypical adult cognitive emotional processes. We analysed multimodal magnetic resonance imaging (MRI) data collected from N ∼ 300 healthy adolescents (51%; female; 14-26 years) each scanned repeatedly in an accelerated longitudinal design, provide analyzable dataset 469 scans 448 MRI scans. estimated the morphometric similarity between possible pair 358 cortical areas on a feature vector comprising six macro- micro-structural metrics, resulting network (MSN) for scan. Over course adolescence, we found that increased paralimbic areas, e.g., insula cingulate cortex, but generally decreased neocortical areas; these results were replicated independent developmental cohort (N 304). Increasing hubness nodes MSNs was associated with strength coupling their connectivity. Decreasing reduced structure-function diverse connections corresponding fMRI networks. Neocortical became more structurally differentiated functionally integrative metabolically expensive process linked thinning myelination; whereas specialised affective interoceptive functions less differentiated, hypothetically predicted by transition peri-allocortical pro-isocortical organization cortex. Cytoarchitectonically distinct zones cortex undergo neurodevelopmental programmes during adolescence.