North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic
Caribbean
0303 health sciences
Research
Climate
Dominican Republic
Infectious and parasitic diseases
RC109-216
Dengue Virus
Genomic epidemiology
Serogroup
Dengue virus
Article
Disease Outbreaks
Dengue
03 medical and health sciences
Humans
Phylogeny
DOI:
10.1101/2024.02.14.24302795
Publication Date:
2024-02-15T22:10:27Z
AUTHORS (22)
ABSTRACT
SummaryWe employ a multidisciplinary approach, integrating genomics and epidemiology, to uncover recent dengue virus transmission dynamics in the Dominican Republic. Our results highlight a previously unknown north-south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures. These findings provide information for targeted interventions and resource allocation, informing as well towards preparedness strategies for public health agencies in mitigating climate and geo-related dengue risks.
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