North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic

Caribbean 0303 health sciences Research Climate Dominican Republic Infectious and parasitic diseases RC109-216 Dengue Virus Genomic epidemiology Serogroup Dengue virus Article Disease Outbreaks Dengue 03 medical and health sciences Humans Phylogeny
DOI: 10.1101/2024.02.14.24302795 Publication Date: 2024-02-15T22:10:27Z
ABSTRACT
SummaryWe employ a multidisciplinary approach, integrating genomics and epidemiology, to uncover recent dengue virus transmission dynamics in the Dominican Republic. Our results highlight a previously unknown north-south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures. These findings provide information for targeted interventions and resource allocation, informing as well towards preparedness strategies for public health agencies in mitigating climate and geo-related dengue risks.
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