North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic

• DOI: 10.1101/2024.02.14.24302795
• Publication Date: 2024-02-15T22:10:27Z
• Authors: Isaac Miguel; Edwin P. Feliz; Robinson Agramonte; Pedro V. Martinez; Carlos Vergara; Yvonne Imbert; Lucia De la Cruz; Nurys de Castro; Odalis Cedano; Yamilka De la Paz; Vagner Fonseca; Gilberto A. Santiago; Jorge L. Muñoz-Jo...; Armando Peguero; Robert Paulino-Ra...; Nathan D. Grubaugh; Ana Maria Bispo d...; Luiz Carlos Junio...; Jairo Mendez Rico; José Lourenço; Leticia Franco; Marta Giovanetti
• Keywords: Preparedness

We employ a multidisciplinary approach, integrating genomics and epidemiology, to uncover recent dengue virus transmission dynamics in the Dominican Republic. Our results highlight previously unknown north-south pathway within country, with co-circulation of multiple lineages. Additionally, we examine historical climate data, revealing long-term trends towards higher theoretical potential for due rising temperatures. These findings provide information targeted interventions resource allocation, informing as well preparedness strategies public health agencies mitigating geo-related risks.