Positioning Genomic Features in Biomedical Knowledge Graphs using the Homo sapiens Chromosomal Location Ontology for GRCh38 (HSCLO38)

• DOI: 10.1101/2024.02.15.580505
• Publication Date: 2024-02-18T22:35:10Z
• Authors: Taha Mohseni Ahooyi; Benjamin J Stear; Deanne M. Taylor
• Keywords: Homo sapiens

The Homo sapiens Chromosomal Location Ontology for GRCh38 (HSCLO38) represents a knowledge-graph-ready framework connecting genomic features at multiple resolutions. We present the methodology behind development of HSCLO38 and its integration with current standards application in biomedical research. explore performance scalability specific use cases handling large-scale data knowledge graph.