Identification of Inhibitors ofChikungunyavirus nsP2 ATPase

• DOI: 10.1101/2024.12.02.625520
• Publication Date: 2024-12-03T04:50:36Z
• Authors: Hernan Navarro; John E. Scott; Ginger R. Smith; Pegah Ghiabi; Elisa Gibson; Peter Loppnau; Rachel J. Harding; Mohammad Anwar Ho...; Muthu Ramalingam ...; Kenneth H. Pearce; Eric M. Merten; Timothy M. Willson; Peter J. Brown
• Keywords: RNA Helicase A

Non-structural protein 2 (nsP2), which plays an essential role in replication of CHIKV, contains a protease, helicase, and methyltransferase-like domain. We executed simple screen using malachite green to detect compounds that decreased ATP hydrolysis tested library diverse find inhibitors CHIKV nsP2 helicase.